Seven former Cardinals have appeared in MLB games during the 2019 season: Nick Burdi, Adam Engel, Chad Green, Matt Koch, Brendan McKay, Josh Rogers, Will Smith, and Nick Solak Early in its history, Louisville played many home games at Eclipse Park in Louisville, until the venue burned down in 1922.

Other early venues included the Belknap Campus Diamond, Shawnee Park, Manual Stadium, and St. Xavier Field.

The grandstand that allowed professional baseball to be played at the venue in the first half of the 20th century was torn down in 1961.

[3][5] Since partway through the 2005 season, the program has played at Jim Patterson Stadium, located on Louisville's campus.

The venue has a capacity of 4,000 spectators, cost $8.5 million, and is named for businessman and former Louisville baseball player Jim Patterson.

In effort to build JPS, Tino Martinez donated money and has his initials above the press box behind home plate.

Dan McDonnell, the program's current head coach, is Louisville's wins leader, with 605.