The team has advanced to the NCAA Women's soccer tournament 5 times, never making it past the second round.

[2] The Louisville women's soccer program began in 1985, under the direction of head coach Chip Wilkinson.

Sandy Davis was hired as the head coach for one year, 1988, and lead the team to a 6–11 record.

In 1989, Jeff Yan and Melissa Mattingly were co-head coaches and the team saw no improvement finishing 6–10–0.

The team saw a big jump in 1993, when they finished with their first winning season in program history at 11–7–0.

The downturn continued in 1997 with a 7–13–0 season as Karla Thompson took over as head coach after a 5–1 start and saw out the decade.

2009 proved to be a bump in the road, as the team finished 5–11–1, seventh in the division, and did not qualify for the conference tournament.

The 2010s began well, with the Cardinals winning double digit games in the first four years of the decade.

Their membership in the AAC would last only one year, and the team moved to the Atlantic Coast Conference in 2014.

2018 proved to be a turnaround year, with the Cardinals finishing 12–7–0 and qualifying for both the ACC and NCAA tournaments.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.