The Louisville and Indiana Railroad (reporting mark LIRC) is a Class III railroad that operates freight service between Indianapolis, Indiana and Louisville, Kentucky, with a major yard and maintenance shop in Jeffersonville, Indiana.

[1] Previously, it was owned by Penn Central, and before that, the Pennsylvania Railroad.

It serves the cities of Franklin, Sellersburg, Seymour and Columbus, Indiana, and also serves the former Clark Maritime Center, now Port of Indiana, Jeffersonville.

In Indianapolis, the LIRC interchanges with the Indiana Rail Road at the Senate Avenue Terminal.

The SIR had ceased operations in 2020, and the purchase opened up a new connection to CSX along with the opportunity for the LIRC to add additional rail-served customers in the future.