It was released as the second single from the album in June 1998 in multiple CD versions, some of which featured Dylan's live performance of the song at the 1998 Grammy Awards.

They also compare the sound of his "dark, sepulchral" vocals, which were distorted by producer Daniel Lanois, to a classic horror film, and call the results "mesmerizing".

In an article accompanying the list, critic Justin Cober-Lake called it a "dark, spacious cut with plenty of patience" that "grows darker with every listen".

[16] During Dylan's live televised performance of the song at the 1998 Grammy Awards, Michael Portnoy, who had been hired as a background dancer, spontaneously jumped in between the band and danced shirtless with the words "Soy Bomb" painted on his chest.

[18] A live version performed in Nashville, Tennessee on February 6, 1999, was made available to stream on Bob Dylan's official website in June 1999.

[20] “Love Sick” was used in a 2004 television advertising campaign for Victoria’s Secret, featuring Dylan and Brazilian model Adriana Lima, that was directed by photographer Dominique Issermann[21] and shot on location in Venice, Italy.

[23] In his memoir Soul Mining: A Musical Life, producer Daniel Lanois wrote approvingly of the ad, "I felt relieved when the ultimate conclusion to our work turned up on television.

[24] The song has been covered by many artists, including The White Stripes,[25] Ryan Adams,[26] Duke Robillard[27] and Mariachi El Bronx.