[1][5] She studied at an acting school in New York and later appeared in a national commercial for JC Penney.

[1][7] The following year, she appeared in two drama films that premiered at 2019 Sundance Film Festival: Share and played a leading role in Selah and the Spades.

[10][11] In 2020, Simone played one of leads in writer-director Zoe Lister-Jones' horror film The Craft: Legacy, a sequel to the 1996 film The Craft.

[12][13][14] In 2021, Simone starred in the first season of Starz crime drama series, Power Book III: Raising Kanan.

[15] In 2022, she was cast opposite Tobias Menzies Apple TV+ limited series, Manhunt.