Lovre Kalinić made his HNK Hajduk Split debut on 23 April 2011, under manager Ante Miše at the age of 21 years and 20 days, in a Prva HNL match against NK Slaven Belupo, which his side won 2–1.

He made his return on 28 July 2016, where Hajduk defeated FC Oleksandriya 3–0 in the Third Round of the 2016-17 UEFA Europa League qualifying at CSC Nika Stadium, keeping a clean sheet.

[9] On 27 December 2016, Hajduk announced that Lovre Kalinić had played his last game for the club, with a move to Belgian First Division A side K.A.A.

On 21 December 2018, English Championship club Aston Villa announced that they had reached an agreement with Gent to sign Kalinić at the start of the January transfer window.

[11] He officially joined on 1 January 2019 and made his debut four days later in a 3–0 defeat in a home FA Cup tie against Swansea City.

[12] His league debut came a week later in another 3–0 defeat, this time against Wigan Athletic, which was followed by a 2–2 draw with Hull City – meaning that Kalinić had conceded 8 goals in his first 3 games.

On 22 December 2020, after making no appearances for Villa in the 2020–21 season up to that point, it was announced that Kalinić would go out on loan to Hajduk Split, where he started his career.

He was an unused substitute at the delayed UEFA Euro 2020, as Livaković played all four matches, and remained on standby list for the 2022 FIFA World Cup, as Ivica Ivušić and Ivo Grbić were chosen to be reserve goalkeepers.

Kalinić's last game for Croatia was a november 2019 friendly against Georgia, where he failed to save a weak shot from Giorgi Papunashvili, giving Georgians the lead.