Beginning as an impromptu recording session in 2010, Low Cut Connie gradually evolved into a vehicle for Weiner's songwriting and his onstage persona.

"[2] Low Cut Connie has also gained notoriety for attracting high-profile endorsements such as a surprise inclusion on Barack Obama's Spotify Summer Playlist in 2015,[3] and a personal association with Elton John, who has called the band one of his favorites.

[6] Weiner started the project that would become Low Cut Connie with former members Dan Finnemore (from Birmingham, England) and Neil Duncan (from Gainesville, Florida).

[10] Independently recorded and released in 2011, Get Out the Lotion garnered surprising critical attention, including an "A−" from Robert Christgau writing for MSN,[11] and high marks from NPR's Ken Tucker, who praised Weiner's "buzzsaw yowl.

"[12] The album also prompted Merrill Garbus to name Low Cut Connie her "favorite artist of the year,"[13] and was awarded 3.5 out of 5 stars by Rolling Stone, which described it as "what indie rock might sound like were it invented in Alabama in the late Fifties.

"[24] In his four star review, Rolling Stone writer David Fricke called Dirty Pictures (Part 2) a "stand-alone triumph of missionary zeal."

Low Cut Connie's sixth album features principal member Adam Weiner with guitarist and long-time collaborator Will Donnelly, as well as a rotating cast of nearly 30 different musicians.

Private Lives earned critical praise upon its release, with Robert Christgau grading the double-LP an "A−", and calling it "meaty, purposeful, evolved, virtuosic garage-rock with an evangelical edge.

With music venues shuttered and his touring band in quarantine, Weiner performed a livestream concert for a virtual audience out of his South Philadelphia home on March 19, 2020.

[41] On February 20, 2021, Tough Cookies, in collaboration with the Rock & Roll Hall of Fame, began airing regular features spotlighting the museum's historical artifacts, exhibits, and inductees.

[42] In addition to critical praise, the band has garnered support from several high-profile individuals including Barack Obama, Elton John, Bruce Springsteen, Howard Stern, Rob Thomas and Nick Hornby.

[44] Weiner posted on Facebook that they were "completely humbled and honored and confused" by their inclusion alongside artists like Stevie Wonder, Aretha Franklin, and Bob Dylan.

[45] On September 12, 2018, Elton John dedicated a song to Low Cut Connie at his sold-out show at the Wells Fargo Center in Philadelphia.

Before performing "Don't Let the Sun Go Down on Me," Elton John announced, "There's a band that I love at the moment so much called Low Cut Connie, who are also from Philadelphia.

"[46] Low Cut Connie had previously been featured on Elton John's radio show Rocket Hour on Beats 1 in July 2017[47] and August 2018.

[52] On August 13, 2018, Low Cut Connie made their network television debut, performing "All These Kids Are Way Too High" off of Dirty Pictures (Part 2) on Late Night with Seth Meyers.