Located within the Ozarks, the first settlement was along Old Wire Road in the 1840s, and although destroyed during the Civil War, the community was reestablished by J. R. McClure and thrived when the St. Louis–San Francisco Railway came through the area in the 1880s.

[3] Lowell is located in southern Benton County and is bordered by the cities of Springdale to the south, Cave Springs to the west and Rogers to the north.

4 miles (6 km) to the east is Beaver Lake, a large reservoir of the White River.

The area does not have the usual principal-city-with-suburbs morphology; instead, the four principal cities are located in a line along Interstate 49.

As of the 2020 United States census, there were 9,839 people, 3,277 households, and 2,302 families residing in the city.

Public education for elementary and secondary students is provided by Rogers School District.

Interstate 49 and U.S. Route 71 pass to the west of downtown Lowell, with access to the city at Exit 78 (Arkansas Highway 264).

Wastewater is collected by gravity sewer and sent to a lift station near the Monroe Avenue exit on I-49.

It is then pumped south, eventually being treated at the Springdale Wastewater Treatment Plant.