Located about 8 miles (13 km) southeast of Youngstown, it is part of the Youngstown–Warren metropolitan area.

Lowellville sits on the Pennsylvania–Ohio border, just west of Mahoningtown, Hillsville, and New Castle, Pennsylvania.

33.9% of all households were made up of individuals, and 19.5% had someone living alone who was 65 years of age or older.

The racial makeup of the village was 99.22% White, 0.08% African American, 0.08% Asian, and 0.62% from two or more races.

32.5% of all households were made up of individuals, and 19.4% had someone living alone who was 65 years of age or older.

Lowellville is served by the Hometown Journal, a local weekly newspaper.