While its boundaries are not precise, the toponym usually refers to the shopping, office, and residential districts to the north and west of Seattle Center.

In early April 2021, the Seattle City Council passed a resolution that officially recognized changing the name of the area previously known as Lower Queen Anne to Uptown.

[2] However, as no borders for neighborhoods in the city of Seattle have been clearly defined, the boundaries of Lower Queen Anne remain merely set by popular opinion.

[5] Local radio station KEXP-FM moved its headquarters to Lower Queen Anne in a building adjacent to the Climate Pledge Arena in December 2015.

[9] Outreach, a sales software company, moved their offices to Lower Queen Anne in 2018, filling a space previously held by Big Fish Games.