Lowesville is a census-designated place (CDP) in Lincoln County, North Carolina, United States.

North Carolina Highway 16, a four-lane freeway, passes through the east side of the community, leading northwest 24 miles (39 km) to Newton and southeast 17 miles (27 km) to Charlotte.

It is paralleled by old Highway 16 (NC-16 Business), a two-lane road that runs through the center of Lowesville.

NC 73 forms the northern edge of the CDP; it leads east 9 miles (14 km) to Interstate 77 in northern Huntersville and west 15 miles (24 km) to Lincolnton, the Lincoln county seat.

19.7% of all households were made up of individuals, and 8.2% had someone living alone who was 65 years of age or older.