[3] Lowndes County comprises the Columbus, MS Micropolitan Statistical Area.

[4] Since the late 20th century, it has been designated as one of three counties in the Golden Triangle region of the state.

This upland area was settled by European Americans who wanted to develop cotton plantations to produce what became the largest commodity crop in the state.

This form of racial terrorism was at its height in the decades around the turn of the 20th century, which followed the state's disenfranchisement of most blacks in 1890 through creating barriers to voter registration.

[5] Lowndes County lies on the east side of Mississippi, bordering the U.S. state of Alabama.

[8] As of the 2020 United States Census, there were 58,879 people, 22,436 households, and 14,654 families residing in the county.

Lowndes County is within the service area of the East Mississippi Community College system.

[17] The Golden Triangle Campus is located in Mayhew, an unincorporated area in Lowndes County.