[5] In '74, Towson would prevail in the 1974 NCAA Division I Men's Lacrosse Championship to claim its first national title, defeating the Hobart Statesmen 18–17 in double overtime.

[7] The Tigers would continue to make the tournament on a regular basis on legendary coach Carl Runk, while Loyola struggled to compete with Towson.

Dave Cottle's 1990 Greyhounds finished as national runner-up[9] and the following season would result in Runk's squad losing to North Carolina in the championship.

The Tigers would endure a four-year tournament drought of their own between 1996 and 2001 before new coach Tony Seamen would lead Towson to another Final Four.

In 2006, new head coach Charley Toomey took over for Loyola and would return to the tournament the following year, but neither team was viewed as a serious contender at the national stage.

[12][13] New Tigers coach Shawn Nadelen quickly built a worthy competitor to Loyola,[14] though the Greyhounds would get the best of their rival in the 2016 tournament to reach another Final Four.

[15][16] Towson would reach the semifinals the next year[17] and, in 2019, would knock off another top-ranked Loyola,[18] sending the Tigers to their first appearance at the top of the national polls in program history.