In 1963, the school was eventually transplanted to its present campus, followed by the introduction of the ISC course and an affiliation with the Cambridge University, due to the efforts of the third Principal, Fr.

John Kunjaparambil, S.J., the fifth Principal, introduced weekly assemblies, the offices of the School Captain and the General Secretary, in May 1964.

He also introduced four houses - Panthers, Leopards, Lions and Tigers, and is also credited with the promotion of sports and other activities in the school.

[3] Loyola has been affiliated to the Council for the Indian School Certificate Examinations (CISCE), New Delhi, since its founding.

When the Government of Kerala abolished the university affiliated Pre-Degree Course (PDC) and replaced it with the State Council for Educational Research and Training (SCERT) affiliated Higher Secondary Course (HSC), Loyola also adopted the newly introduced course as a higher secondary level option for students.

LENS, Loyola's student newsletter, reported that poor demand was the reason for the phasing out of the SSLC course.

In the decade after 2000, Loyola started a separate Central Board of Secondary Education (CBSE) affiliated section in the same campus.

[15][16][17][18][19][20][21] In 2006, Loyolites won the inaugural edition of the National Aerospace Olympiad conducted by the Aeronautical Society of India in Chandigarh, winning both the quiz rounds in the process.

[25] Since 1996, the higher secondary students have organized a talent show called LA Fest (abbreviation for Life and Arts Festival).

LA Fest was discontinued by the school temporarily in 2016 and was replaced with LOUD (Loyola Union Debate)in 2019.

The school celebrates Teachers' Day, with the older students taking over the teaching of the younger classes.

In anticipation of the India - New Zealand T20 match in Thiruvananthapuram on 7 November, the 12th students directed a video in dedication to all the Malayalis who love cricket.

[citation needed] Football is popular at Loyola, with several games on the main field during lunch breaks.

[30] In November 2003 Loyola's team made the semi-finals of the sports festival held at Christ Nagar School, Thiruvananthapuram.

[32] The 2017-18 school team won the South Zone CBSE Sahodaya and also bagged the best player and best goalkeeper awards.

The seven red bars at the top are from the shield of Oñaz-Loyola, the family of Ignatius of Loyola, the founder of the Society of Jesus.

The renowned architect Laurie Baker, whose son Tilak studied in Loyola, designed the crest.

Loyola School publishes an annual journal/yearbook called The Loyolite, chronicling the important events of the current academic year.

It also includes an annual report written by the Principal, group photographs of all classes as well as the staff, contributions by alumni as well as by the students in Malayalam, English, and Hindi.

Loyola English News Service is a periodical brought out by the senior students covering events on campus.