Loyola's law school opened in 1914 and is now located on the Broadway Campus of the university in the historic Audubon Park District of the city.

Judge John St. Paul was the founding dean, "choosing the faculty and preparing the curriculum".

In 1925, the law school opened a day division to better serve the needs of its students, as the coursework was expanded to a four-year program.

According to the law professor blog, The Faculty Lounge, based on 2012 ABA data, only 48.6% of graduates obtained full-time, long term, bar admission required positions (i.e., jobs as lawyers), 9 months after graduation, ranking 135th out of 197 law schools.

With the school's special focus on the study of international law, over the course of the years, programs have established in the following countries: According to the College of Law's 2022 ABA-required disclosures, 79% of the Class of 2022 obtained full-time, long-term, bar passage-required employment nine months after graduation, excluding solo practitioners.