[3] His strength on the ball, accurate finishing and pace made him a vital part of the side that fell in the semi-finals of the 2004 Copa Libertadores de América.

Luís Fabiano was labeled the "bad boy" of Brazilian football when playing for São Paulo after a number of brawls.

During a 2003 Copa Sudamericana match for São Paulo against River Plate of Argentina, a fight between the players broke out.

[5][6] At Porto, Luís Fabiano was reunited with his international teammate Diego, who he played with on the Brazil squad at the 2004 Copa América.

[5] Luís Fabiano transferred to Sevilla ahead of the 2005–06 season, replacing his compatriot and former São Paulo teammate Júlio Baptista, who in turn had just become a Real Madrid player.

On 30 August 2010, Luís Fabiano put an end to the speculation with a move away from Sevilla by signing a contract extension until 2013.

On 29 July 2012, playing against Flamengo, Luís Fabiano scored two goals and thus became the seventh-most prolific goalscorer of São Paulo's history, outscoring Leônidas.

[16] On 28 June 2009, Luís Fabiano scored two goals in the 2009 FIFA Confederations Cup final win against the United States.

[18] Luís Fabiano scored his first international goal in nine months with a right-footed strike against Ivory Coast on 20 June 2010 in the 2010 World Cup.

Luís Fabiano was a prolific, skilful and powerful goalscorer, with excellent creativity, dribbling skills, and technical ability; he also had a strong physical presence against defenders and goalkeepers.

Even as the top goalscorer in the 2013 season with 16 goals by June, he had received several red cards, hindering São Paulo in important games.