Luca Antonino Mezzano (born 1 August 1977) is an Italian football coach and former player who played as a defender.
Born in Turin, Mezzano started his career at hometown club Torino, and joined Internazionale in 1997.
He returned to Torino in 2001, spending four seasons with the club before playing with Bologna, Treviso and Triestina in Serie B.
With the Italy youth team, he won the 2000 UEFA European Under-21 Football Championship and was a quarter-finalist at the 2000 Summer Olympics.
This biographical article related to association football in Italy, about a defender born in the 1970s, is a stub.