After she married actor James Gleason, she realized stage success in New York City in a production of The Shannons of Broadway (1927), written by her husband.

[1] In 1945, they made The Clock, with Lucile playing the role of Mrs. Al Henry, the wife of her husband's character.

The story centers around Lucile's performance in two radio programs which threaten to derail her husband's advertising business.

On December 26, 1945, Russell Gleason was in New York City when he fell to his death out of a fourth story window in the Hotel Sutton.

[citation needed] Gleason died in her sleep, apparently of heart disease in 1947,[4] aged 59, at her home in Brentwood, California.