As well as fronting television news, Millarini has also reported for ITV's flagship current affairs programme, On Assignment.
[2] On 9 April 2021, she broke the news of the death of Prince Philip, Duke of Edinburgh in a special announcement on ITV.
[12] In December 2021, Millarini was one of the contestants on the BBC One quiz show The Weakest Link, with the new host Romesh Ranganathan.
[13] In May 2022, Millarini took part in the ITV hosted celebrity athletics show The Games,[1][2] and in November 2022, appeared alongside her fellow ITN newsreader Nina Hossain in the BBC Two show Celebrity Antiques Road Trip.
[16][17] She also supports the Cats Protection League, The Humane Society and People for the Ethical Treatment of Animals.