[1][2] The show features Melissa Bardin Galsky as Lucy, the daughter of the Devil, who is voiced by H. Jon Benjamin.

The voice of Lucy was changed from Jessi Klein to Melissa Bardin Galsky; the third Special Father character, a black man missing an eye, was discarded and replaced with the Special Sister; and the cover of "Maneater" used as opening music was replaced for rebroadcasts.

The show follows the titular 21-year-old Lucy Morningstar, who lives in San Francisco and has been ordained by her father, the devil, to fulfill her destiny as the Antichrist, whether she likes it or not.

Along the way she meets up with a DJ named Jesús, who turns out to be the Second Coming of the messiah, and the two begin dating from the first episode after Lucy saves him from a fire created by her father to kill him.

At the same time a group of "Special Clergy", two priests and a nun, are on a mission from the Vatican to find and destroy Lucy.