From 1892 until her death in 1945, she was the wife of Stanley Baldwin, three-time Prime Minister of the United Kingdom.

She often travelled with her husband during his time as prime minister, and she was an excellent speaker who found her own voice in politics.

In 1928, she became vice-chairman of the newly established National Birthday Trust Fund to address the high incidence of maternal mortality.

She was particularly concerned with reducing the pain of childbirth, and lobbied for new funds to make anaesthesia affordable for low-income women.

[8] It was commemorated by the prime minister on 16 April 1929, with a bronze dedication plaque over the main entrance reading "What she wanted most in the world.

[11] Baldwin also wrote valuable notes of two major events in politics, the fall of the Lloyd George ministry and the Abdication Crisis.