In February 2006 it was announced she would be playing a "feisty", beautiful Marian in the BBC family drama series Robin Hood, alongside Jonas Armstrong.
[11] In November 2011, it was revealed that Griffiths would play Nora, the sister of vampire Eric Northman (Alexander Skarsgård), in the fifth season of HBO's True Blood.
Griffiths was originally cast in Constantine as the female lead Liv Aberdine, the daughter of a late friend, who comes to discover that she has the ability of seeing the supernatural world among us.
Some of Griffiths' final scenes in the pilot were reshot to explain why her character doesn't join Constantine in his adventures, as had been foreshadowed and originally intended.
[14] In April 2015 Griffiths was cast in the AMC series Preacher as Emily Woodrow, a character described as a "no-nonsense" single mother, waitress, church organist, bookkeeper and the loyal right hand of Jesse Custer (Dominic Cooper).