Founded in 1922 in a garage on Franklin Street,[1] the team had competed for several seasons during the 1930s in the New England Division of the American Soccer League,[2] but for most of its existence it has been an amateur or semi-professional club.

John Palhete was the team's first coach[3] and they play their home games in Lusitano Stadium, which is owned by the club.

In the 1937–38 American Soccer League, the club played as Lusitano S.C..[4][5] During the 1938–39 American Soccer League, the club started to use the name Ludlow Lusitano[6] to play the ASL's New England Division, making it to the final of the National Amateur Cup in 1952.

[7] For the 1956/57 season, the team returned to be known as Ludlow S.C.. After the division folded in 1953, the club took part in different regional leagues before finally joining the ASL.

[8] In total, the Gremio Lusitano played the National Challenge Cup four times.