Luigi Maglione (2 March 1877 – 22 August 1944) was an Italian prelate of the Catholic Church who joined the diplomatic service of the Holy See in 1908, served as a papal nuncio from 1920 to 1935.

Born in Casoria, Maglione was educated at the Almo Collegio Capranica and Pontifical Gregorian University, from where he obtained doctorates in philosophy and theology, in Rome.

He received his episcopal consecration on the following 26 September from Cardinal Pietro Gasparri, with Archbishops Bonaventura Cerretti and Lorenzo Schioppa serving as co-consecrators, in the church of Santa Maria in Trastevere.

Pope Pius XI created him Cardinal-Priest of Santa Pudenziana in the consistory of 16 December 1935, and then Prefect of the Sacred Congregation of the Council on 22 July 1938.

Upon his death, Pius XII assumed the duties of the office himself, with assistance from Domenico Tardini and Giovanni Battista Montini (who later became Pope Paul VI).