During his second stint with the club, he played a pivotal role in helping Milan to win the 1961–62 Serie A title and the 1962–63 European Cup.

[5] Radice began his managerial career with Monza, winning the 1966–67 Serie C Girone A; he remained at the club from 1966 until 1971, apart from a year-long spell with Treviso between 1968 and 1969.

After a brief time at Cagliari in 1975, Radice moved to Torino, where he became the first and only coach to lead the club to the Scudetto since the Superga tragedy, winning the title during the 1975–76 season.

[2] On 17 April 1979, he was involved in a car accident on the Autostrada dei Fiori in which former football player Paolo Barison lost his life.

[10] In 1983, he replaced Enrico Catuzzi as the manager of Bari in Serie B, coaching the Galletti for the remaining 13 games of the season.

However, a mid-season feud with the club's chairman Vittorio Cecchi Gori led to the departure of Radice, and Fiorentina nose-dived in the standings.