Luigi Serafini (6 June 1808 – 1 February 1894) was a Roman Catholic bishop and cardinal.
He was born in Magliano Sabina in 1808, and ordained a priest in 1853.
In 1884, he was appointed Prefect of the Apostolic Signatura.
The following year, he was appointed Prefect of the Sacred Congregation of the Council.
This article about an Italian Catholic cardinal is a stub.