A product of Sevilla FC, Luis Alberto was born in San José del Valle, Province of Cádiz,[4] and he spent his first three seasons as a senior with the reserves in the Segunda División B, scoring 15 goals in the second.

[8] He made his official debut on 2 September by playing two minutes in a 2–0 home win over CE Sabadell FC,[9] and finished the campaign as second top scorer in the squad, only behind Gerard Deulofeu.

[24][25] On 11 June 2024, it was announced that Luis Alberto would join Al-Duhail SC of the Qatar Stars League on a three-year deal from 1 July;[26] the transfer reportedly commanded a €12 million fee, plus add-ons and a 25% sell-on clause in favour of Liverpool.

[27] Luis Alberto earned his only cap for the Spain under-21 team on 5 February 2013, coming on for Valencia CF's Paco Alcácer midway through the second half of a 1–1 friendly draw in Belgium.

[29] A talented and versatile playmaker, Luis Alberto usually plays either in a central role as an attacking midfielder or as a left winger, a position which allows him to cut inside and shoot on goal with his stronger right foot.

[33] Although he lacks physicality, he is known for his awareness, technical qualities, ball control and dribbling skills,[30][31] as well as his passing, crossing and vision, which allow him to create chances and provide assists for teammates.