There is no record of his priestly ordination, but on 20 November 1717 he was named canon of the Toledo Cathedral, where he was dean from 7 March 1733.

At the proposal of King Ferdinand VI of Spain, he was named Cardinal in the consistory of 18 December 1754 by Pope Benedict XIV.

The next year, on 3 August 3 1755, he was appointed Archbishop of the Archdiocese of Toledo to replace Luis Antonio de Borbón y Farnesio after the latter's resignation.

He opposed the expulsion of the Jesuits, and was therefore temporarily banned from the city of Madrid (then part of the archdiocese of Toledo).

He is buried in the Convento de la Purísima Concepción, Toledo, which he restored.