He was an unsuccessful Argentine Senate candidate for the UCR in 2005, and for Vice Governor of Buenos Aires Province, with nominee Ricardo Alfonsín, in 2007.

An actor with extensive film, television and theatre credits, he portrayed leading roles in acclaimed pictures such as La tregua (1974), Juan que reía (1976), Darse cuenta (1984), Esperando la carroza (1985), Made in Argentina (1986), Cien veces no debo (1990), Convivencia (1993), Una sombra ya pronto serás (1994), De mi barrio con amor (1995), and Los pasos perdidos (2001).

He also starred in Gastón Duprat & Mariano Cohn's comedy film Mi obra maestra (2018), together again with Guillermo Francella.

Cohn & Duprat wrote and directed the series, which features a supporting cast that includes Robert De Niro.

[5] In July 2017, the Argentine Association of Actors issued a harsh statement criticizing Brandoni for some statements made at the time on the television program Intratables, where he described as "verse" (meaning "false") the current denomination of "civil-military" regarding Argentina's last dictatorship, while denying there was any important civilian participation or decision-making in the military government of the dictatorship.