He was the third Puerto Rican to play in Major League Baseball (after Hiram Bithorn and Luis Olmo).

[1] Márquez played in a total of 68 games in the major leagues, split in two seasons between the Boston Braves, the Chicago Cubs and the Pittsburgh Pirates.

Márquez played in the Negro leagues with the New York Black Yankees, Baltimore Elite Giants and Homestead Grays.

In a history of Puerto Rican baseball, Thomas Van Hyning described Márquz as "a complete ballplayer who could hit, run, throw, play good defense and provide power when needed.

He played for the Portland Beavers in the Pacific Coast League and for the Milwaukee Brewers, the Toledo Sox, and the Dallas-Fort Worth Rangers in the American Association.