Luis Manuel Orejuela García (born 20 August 1995) is a Colombian professional footballer who plays as a right-back for São Paulo FC, on loan from Independiente Medellín.

[2] Initially a backup option, he became a regular starter for the club from the 2016 season onwards; he scored his first senior goal on 20 November of that year, netting the opener in a 3–1 away defeat of Rionegro Águilas.

[4] Initially assigned to the reserves in Eerste Divisie, he made his first team debut on 20 September, starting in a 5–1 away routing of SVV Scheveningen for the KNVB Cup.

[5] Orejuela made his debut in the Eredivisie on 17 December 2017, coming on as a half-time substitute for Deyovaisio Zeefuik in a 2–1 away win over AZ Alkmaar.

[10] Orejuela represented Colombia at under-20 level before receiving a call up to the full side on 13 March 2019, for two friendlies against Japan and South Korea.