[2][1] Early in his life Guzmán wanted to enter Menudo, but was unable to do it, eventually forming friendships with several former members.

[3] After completing his studies in the institutionʻs Department of Drama, Guzmán moved to Mexico in 1999, interested in pursuing a career in the telenovela industry.

Guzmán has expressed that the most important role of his career is as El Pantera in the TV series of the same name.

In his youth Guzmán was a follower of several fictional superheroes, including Atom Ant and ThunderCats, which influenced his acceptance for the role.

On June 26, 2013, it was confirmed that Luis Roberto Guzmán (along with Angelique Boyer and Sebastián Rulli) would star in Angelli Nesma's Lo Que La Vida Me Robó, a remake of Ernesto Alonso's Bodas de odio produced in 1983.