There, he fought in the relief of Bruges, in the Palatinate, and in the failed attempts to prevent the Capture of Maastricht by the Dutch in 1632.
[2] In 1635 he was again in Italy in the retinue of the Marquis of Leganés who in May 1637 designated him as the successor of Juan de Garay Otáñez y Rada to send his troops to Lombardy in support of the war operations of those years.
However, the ancient privileges evoked by Juan de Garay Otáñez y Rada soon forced the governor to dismiss Guzmán Ponce de Leon, who was sent to Alsace as a cavalry general under the command of the Duke of Lorraine, where he was involved in the campaign of Luxembourg and the Siege of Arras (1640).
In 1648, King Philip IV of Spain appointed him Captain of the company of his "Spanish Guard", a position that obviously also earned him the title of Gentleman of the sovereign's chamber as well as becoming a member of the Council of state for war.
In 1662, he was finally assigned to occupy the position of Governor of the Duchy of Milan, moving back to Italy on 5 June of that year.