Luis de Velasco, 1st Marquess of Salinas del Río Pisuerga (c. 1534 – September 7, 1617) was a Spanish nobleman who was the ninth viceroy of New Spain from January 27, 1590 to November 4, 1595, and again from July 2, 1607, to June 10, 1611.

Because the news that had reached Spain indicated that the colony was in turmoil, he was advised not to disembark at Veracruz, the usual port of entry.

In return, Velasco reduced the taxes that had been levied on the Indians and charged the Real Hacienda to supply lawyers to represent the tribes and ease their entry into the society of the colony.

In autumn of 1595, Velasco selected and appointed Juan de Oñate governor and head of the latter's now famous expedition into North America.

Velasco took preventative measures, including sending an armed force under Captain Pedro González de Herrera to Puebla.

Herrera was to combat the escaped slaves and rebels (Maroons) on the Rio Blanco, who preyed on travelers between Veracruz and Mexico City.

Velasco then arranged for the escaped slaves to found their own village, San Lorenzo de los Negros, near Córdova.

He received in 1610 the embassy of Luis Sotelo and Tanaka Shōsuke, which had sailed from Japan on the Japanese sailship San Buena Ventura, and agreed to send an ambassador to Japan in the person of the famous explorer Sebastián Vizcaíno, with the added mission of exploring the "gold and silver islands" which were thought to be east of the Japanese isles.

Vizcaíno sailed from Acapulco in the San Bernardo on March 22, 1611, with the emissaries from Japan, arriving in Uraga on June 16 of that year.

Vizcaíno, having lost his ship, sailed from Japan October 28, 1613, on board the Japanese galleon San Juan Bautista and arrived back at Acapulco on January 25, 1614.

In 1610 King Philip III made him Marqués de Salinas as a reward for his services, and on December 27, 1610 named him president of the Council of the Indies.