Luis Manuel de los Santos Martinez (born December 29, 1966) is a Dominican former Major League Baseball (MLB) first baseman.

de los Santos played in the majors for three seasons, including stints with the Kansas City Royals (1988-1989) and the Detroit Tigers (1991).

[1] Afterward, de los Santos played professionally in several countries, including Mexico, Taiwan, Japan, and South Korea.

After spending a year in Triple-A Edmonton that did not see him get called up to the majors, de los Santos played in three seasons with the Brother Elephants between 1994 and 1996, which saw him lead the Chinese Professional Baseball League in RBI in 1995.

Following his stint in Japan and a two-season hiatus from baseball, de los Santos played a year for Saraperos de Saltillo and a year for the KBO League's Kia Tigers before playing 50 games for the Baltimore Orioles' Triple-A affiliate, the Rochester Red Wings, in 2002.