In June 2023, González announced her candidacy for president as the Citizen Revolution Movement nominee in the 2023 election, one month after her tenure at the National Assembly ended when the incumbent president, Guillermo Lasso, invoked a measure from Ecuador's constitution known as muerte cruzada.

[10] In 2007, she was a candidate for the National Congress to represent Pichincha Province for the right-wing Social Christian Party (PSC).

[11] In 2008, she worked as an advisor to the Secretariat of Communication and Information of Ecuador, and that same year she became General Coordinator of Human Resources, Institutional Development and Training of the Superintendence of Companies.

[18] On 17 May 2023, when President Guillermo Lasso dissolved the National Assembly through the decree muerte cruzada, González's tenure as an assemblywoman ended.

[19] In 2019, an examination showed González used presidential aircraft to travel to various countries when she was a member of the government, without making a request to the President of the Republic.

[20] The Comptroller's Office found her liable for a total of $880,473 for the irregular use of the presidential plane to travel to tax havens.

[18] On 10 June 2023, González was designated as the presidential candidate for the Citizen Revolution Movement to participate in the 2023 general election, after former Vice President Jorge Glas declined the nomination.

[24] The National Police claimed to have used chemical agents to protect security and public order because of the hostile behavior of González's supporters.

[27][28] However, the next day, the Citizen Revolution Movement stated that the missing requirement was being corrected, and on 20 June the registration was accepted.

[29][30] During her campaign, González had vowed to make former President Rafael Correa a central figure in her administration such as a "principal advisor".

[31] A poll conducted on 9 July, showed González as the front-runner with nearly 34% and former Vice President Otto Sonnenholzner in second place with 17.5%.

[4] In June 2024, Pichincha Province Prefect Paola Pabón announced she would also be running for the RC nomination, challenging González.

[40] In August 2024, Pabón ended her campaign, making González the sole presidential candidate for the RC nomination.

[31] She was described herself as an "animal rights defender" and has repeatedly invoked Correa's political positions and administration on the campaign trail.

[36] During the 2023 referendum, González supported the measure that would have allowed oil exploitation in the Yasuní National Park, citing that it would benefit financial budgets aimed at education and the economy.