Luiz Henrique Mandetta (born 30 November 1964) is a Brazilian pediatric orthopedist and politician, member of the Brazil Union (UNIÃO).

Mandetta was announced on 20 November 2018 as Minister of Health of president Jair Bolsonaro, replacing Gilberto Occhi.

[5] During his time in Congress, Mandetta was most well known for opposing health policies of the leftist Workers Party government, and in particular its “Mais Medicos” program which brought Cuban doctors to Brazil's most far-flung corners.

[10] About the accusations of irregularities when he was Secretary of Health of Campo Grande, Mandetta affirmed a week before the confirmation that he had talked to Bolsonaro about the details of the case.

[16] Bolsonaro has expressed his dissatisfaction with the minister multiple times, and reportedly decided to dismiss Mandetta on 6 April 2020 before backing down due to pressure from his advisors.