On 28 May 2014, at the age of 16 years, five months and five days, Jović made his professional debut against FK Vojvodina in Novi Sad, where he broke Dejan Stanković's record as the youngest goalscorer in a competitive match in the club's history.

From the beginning of the 2015–16 season, Jović started as a first choice in Red Star attack along with Hugo Vieira and scored 3 goals in first 5 games.

[13] On 9 March, he debuted for the club's reserve team in a 2–2 home draw against Sporting da Covilhã in the Segunda Liga.

[15] In June 2017, Jović joined Eintracht Frankfurt on a two-season loan while his new club secured an option to sign him on a permanent basis.

20-year-old Jović became the youngest player to score five goals in a Bundesliga game when he did so in a 7–1 home win over Fortuna Düsseldorf on 19 October 2018.

[19] On 14 March 2019, he scored the only goal, his seventh for the campaign, in a 1–0 win over Inter Milan to secure the club's progression to the quarter finals of the Europa League.

[20] On 17 April 2019, Eintracht Frankfurt exercised a clause in Jović's contract to make his loan move permanent until 30 June 2023.

[27] Jović started both semi-final and final match of 2019–20 Supercopa de España against Valencia (made a assist to Modrić goal) and Atlético Madrid, respectively.

[30][31] On 17 January, in his first match back with his former club, Jović came off the bench and scored two goals within half an hour as Frankfurt defeated Schalke 3–1.

[39] In July 2014, he was called up by youth coach Veljko Paunović to Serbia's U-19 squad for the 2014 UEFA European Under-19 Championship.

[41] On 4 June, he made his international debut in a friendly match against Chile, coming on as a substitute for Aleksandar Mitrović in the 84th minute.

[42] Later in June, Jović was included in the final 23-man squad for the 2018 FIFA World Cup,[43] where he appeared as a late substitute against Brazil.

[57] Red Star Belgrade Benfica Eintracht Frankfurt Real Madrid Fiorentina AC Milan Individual