He has appeared in numerous films including Blade II (2002) as Jared Nomak, One Night with the King (2006) as King Xerxes, Hellboy II: The Golden Army (2008) as Prince Nuada, Tekken (2009) as Steve Fox, Interview with a Hitman (2012) as Viktor, and Traffik (2018) as Red.

He also began to appear in stage musicals including Grease and What a Feeling, and has turned to acting in films full-time, with his first most notable role being the villain in Blade II.

Goss received a CAMIE (Character and Morality in Entertainment) Award for his work in One Night with the King on 12 May 2007 at the Beverly Hills Hotel in Los Angeles.

In the autumn of 2008, Goss returned from filming Hellboy II: The Golden Army in Budapest, Hungary, in which he plays Prince Nuada.

In January 2010, Goss won the role as Frankenstein in Death Race 2[6] which was originally played by Jason Statham in the first film, under the direction from Roel Reiné, which began shooting on location in Eastern Europe in February 2010.