A Republican, he was elected to the United States House of Representatives for Louisiana's 5th congressional district in 2020 but died from complications caused by COVID-19 five days before he was due to take office in the 117th Congress.

He graduated from Ouachita Christian High School and earned a Bachelor of Science in computer information systems from Louisiana Tech University in 2003.

[14] In October, he had encouraged Louisiana officials to relax pandemic restrictions, warning, "We're now at a place if we do not open our economy, we're in real danger.

[15] After his condition deteriorated, he was transferred to the intensive care unit (ICU) of Ochsner LSU Health Shreveport on December 23.

[17][18] Louisiana Governor John Bel Edwards ordered flags in the state to be flown at half-staff on the day of Letlow's funeral.