The Lule people were made up of the following groups: Esistiné, Tokistiné, Oristiné, Axostiné, Tamboriné, Guaxastiné, and Casutiné.

In order to convert them to Christianity, the Jesuits founded a mission near San Isidro de Lules in Tucumán province in 1670.

During the mission's existence, it often traded and sold the Lule and Diaguita indigenous population of the area to members of the landed oligarchy, plantations, and colonial workshops.

In 1708, Esteban de Urízar, the governor of Tucumán, carried out a punitive campaign against the indigenous peoples of the Gran Chaco, including the Lules.

[3] The descendants of the Lules have partly, but incompletely, mixed and acculturated into the predominantly white population and culture of Argentina.