[1][2] Odobescu was state counsellor and advisor on European Affairs and External Relations to the Romanian prime minister from 8 November 2012 to 1 August 2015.

[5][6][7] Soon after, Odobescu attended the Ukraine Recovery Conference in London and met with her Ukrainian counterpart, Dmytro Kuleba, for the first time.

The same day, she held her first meeting since taking office with Spanish Foreign Affairs Minister, José Manuel Albares, with Odobescu stressing that the two countries remain fully committed to strengthening the strategic bilateral association.

[14] She also had her first bilateral meeting with UK Foreign Secretary James Cleverly since she took office, and they discussed the opportunities of strategic partnership, the ways of enhancing cooperation within NATO, and building a stronger alliance together.

[17] On 19 July, ahead of attending the Foreign Affairs Council (FAC) in Brussels as part of the delegation led by President Klaus Iohannis, Odobescu held a bilateral meeting with European Commissioner for Neighbourhood and Enlargement, Olivér Várhelyi, where they discussed the opening of EU accession negotiations for Moldova and for Ukraine.

"[30][31] On 17 August, she spoke to Armenian Foreign Affairs Minister, Ararat Mirzoyan, and they discussed the security developments in the South Caucasus region, with Odobescu welcoming the mediation efforts of Charles Michel.

[38] Odobescu rejected this accusation, stating that it was "undeserved" and that Romania was "not a source or route for illegal migration", and also that it was "difficult to understand and explain" why Austria was opposed.

[41] Odobescu met with Sri Lankan External Affairs Minister, Ali Sabry, and they reviewed the state of political dialogue and discussed the importance of deepening bilateral relations in areas of mutual interest.

[41] Georgian Foreign Affairs Minister, Ilia Darchiashvili, and Odobescu discussed issues of common interest along with ways to deepen the strategic partnership between the two countries.

[41] Odobescu also had a meeting with Nepal's Foreign Affairs Minister, Narayan Prakash Saud, where they underlined their interest in intensifying political dialogue.

[42] Odobescu also met with the Foreign Affairs Minister of Saudi Arabia, Prince Faisal bin Farhan Al Saud, and she reaffirmed Romania's interest in strengthening the political dialogue.

[42] On 21 September, together with Secretary Blinken, hosted the Ministerial Meeting of the Global Network of National Focal Points for Women, Peace and security.

[47][48] Odobescu also met with Deputy Prime Minister for European and Euro-Atlantic Integration, Olha Stefanishyna, and they exchanged views on bilateral dialogue between Romania and Ukraine.