It is located within the Shawnee National Forest in Pope County, Illinois.

[1] It includes the Lusk Creek Canyon National Natural Landmark.

As with other wilderness areas within Shawnee National Forest, the Lusk Creek Wilderness is made of hilly second-growth forested areas that were used, until the land condemnations of the 1930s, as pasture land.

The largest trees in the Lust Creek Wilderness terraces are sugar maples and beeches, while on the slopes the hickory and white oak can be seen.

The wilderness is also noted for a dramatic scenic overlook, Indian Kitchen.