He was born and died in Ferrara, and despite evidence of travels to Rome[1] it is assumed that Luzzaschi spent the majority of his life in his native city.
Luzzaschi is widely remembered due to his association with the famous Concerto delle donne, a private female vocal ensemble founded by Alfonso II, Duke of Ferrara.
In addition to his duties as court organist, as director for the ensemble he composed expert madrigals that required virtuosic vocal skill and advanced musicianship.
Expressing a highly ornamented soprano line, his famous publication, Madrigali...per cantare, et sonare, a uno, e doi, e tre soprani of 1601 contained repertory performed by this expert troupe.
[3] Luzzaschi's surviving canon is limited to: seven books (1571 through 1604) of madrigals for five voices; the 1601 Madrigali per cantare et sonare a 1-3 soprani; a collection of five-part motets; and four keyboard works.