Lycée Notre Dame de Sion Istanbul (Turkish: Notre Dame de Sion Özel Fransız Lisesi) is a French private high school located in the Harbiye, Şişli neighbourhood of Istanbul, Turkey.

They took over the administration of Maison du Saint-Esprit, a boarding school in the Pangaltı neighborhood, which was named after the 1846-built Cathedral of the Holy Spirit next to it, and was run by the Daughters of Charity of Saint Vincent de Paul (French: Filles de la Charité), a society of apostolic life for women within the Catholic Church.

The official opening of the French boarding school under the name Lycée Notre Dame de Sion took place on November 27 of the same year.

From 1863 on, Muslim girls attended the school following the interest of the notable families in the Empire and the approval of the Ottoman Sultan.

[5] A chamber music concert was performed in the school in 2014 in commemoration of harpist Fatma Ceren Necipoğlu, who died at the Air France Flight 447 accident in 2009.