Lycium andersonii is a species of flowering plant in the nightshade family, Solanaceae.

[5] The species is native to the Southwestern United States and northwestern Mexico, where it is distributed in New Mexico, Arizona, California, Nevada, Utah, Baja California, Sinaloa, and Sonora.

It grows from a large fibrous root system which can extend over 9 metres (30 ft) from the base of the plant.

The shrub is rounded in shape with many branches covered in many thin spines up to 2 centimetres (0.79 in) long.

Common associates include creosote bush (Larrea tridentata), yellow palo verde (Parkinsonia microphylla), white bursage, (Ambrosia dumosa), smoke tree (Psorothamnus spinosus), Nevada ephedra (Ephedra nevadensis), hop sage (Grayia spinosa), pale wolfberry (Lycium pallidum), blackbrush (Coleogyne ramosissima), singlewhorl burrobrush (Hymenoclea monogyra), and Joshua tree (Yucca brevifolia).