Lycium berlandieri is a species of flowering plant in the nightshade family known by the common name Berlandier's wolfberry.

It is rarely dominant, but it occurs in many types of desert habitat, including mesquite and saltbush plant communities, creosote, grassland, prairie, and savanna.

In the Sonoran and Chihuahuan Deserts it grows alongside ocotillo (Fouquieria splendens), saguaro (Carnegiea gigantea), range ratany (Krameria parvifolia), ironwood (Olneya tesota), jojoba (Simmondsia chinensis), false-mesquite (Calliandra eriophylla), brittlebush (Encelia farinosa), leatherstem (Jatropha cardiophylla), feather dalea (Dalea formosa), yucca, agave, Opuntia cacti, and acacia species.

In Texas it can be found in sandy arroyos and more saline areas alongside mesquite and hackberry.

Gambel's quail live in habitat where the shrub is common, and they use it for cover and nesting.