Lycosuchus ("wolf crocodile") is an extinct genus of carnivorous therocephalians which lived in the Middle Permian 265—260 Ma existing for approximately 5 million years.

The type and only species, L. vanderrieti, is known from a handful of well-preserved specimens featuring the cranium and lower jaw; the holotype US D173 housed at the University of Stellenbosch, South Africa, is a near complete occluded skull.

995, housed at the Museum für Naturkunde Berlin, Germany, consists of a near complete and isolated lower jaw, along with a partial snout and brain case.

It was a medium-sized predator, reaching 1.2 m (3.8 ft) in length with a skull 23 cm long.,[3] typical of early therocephalians.

L. vanderrieti bore two functional canines in each maxilla, possibly due to a protracted tooth replacement.