The town is part of the Lower Connecticut River Valley Planning Region.

In 1667, the Connecticut General Court formally recognized the East Saybrook plantation as the town of Lyme, named after Lyme Regis, a coastal town in the southwest of England.

Archer, Pleasant Valley, Rogers Lake West Shore, and Sterling City.

[4] The number of Lyme residents registering with the Democratic party has grown in recent years, from 541 in 2015 to 757 in 2022.

Services include connections to Old Saybrook station, served by Amtrak and Shore Line East railroads.