Lyme is a town along the Connecticut River in Grafton County, New Hampshire, United States.

The Dartmouth Skiway is in the eastern part of town, near the village of Lyme Center.

This was once a home to Abenaki Indians, including a band of Sokokis near Post Pond at a place they called Ordanakis.

Later, it would be among the many towns granted by colonial Governor Benning Wentworth along the Connecticut River in 1761.

Many of the 63 grantees lived in Massachusetts and Connecticut, but virtually none of them ever settled in Lyme, and they instead sold or assigned their grants to others.

[citation needed] In the late 1770s, Lyme petitioned (ultimately unsuccessfully) to join Vermont.

The scenic town common is surrounded with houses and public buildings dating from the late 1700s to the early 1900s.

[1] Lyme is drained by Hewes, Grant, and Clay brooks, all flowing to the Connecticut River, which forms the western boundary of the town and the state border with Vermont.

Most human development is in the western half of the town along the Connecticut River and New Hampshire Route 10, known as the Dartmouth College Highway.

The highest point in town is the summit of Smarts Mountain, at 3,238 feet (987 m) above sea level.

[7] Looking at the occupations of employed people in the town over the age of 16, the largest group - 50.9% - is education and health care.

Crossroads Academy,[10] founded in 1991 as a K–8 school in Hanover, is now located on a wooded 140-acre (57 ha) campus at 95 Dartmouth College Highway in Lyme.